comparison of efficacy of intercessional injection of glucantime and cryotherapy with intralesional injection in the treatment of zoonotic cutaneous leishmaniasis:a randomized clinical trial

Authors

abedin saghafipour m.sc. of medical entomology, qom university of medical sciences, qom, iran.

yavar rassi professor, dep. of medical entomology, tehran university of medical sciences, tehran, iran.

mehdi norouze ph.d. student of epidemiology, faculty of health, shahid behshti university of medical sciences, tehran, iran.

abstract

introduction: this study was done to compare the efficacy of interlesional injection of glucantime method and cryotherapy with interlesional injection in treatment of cutaneous leishmaniasis in qom province. methods: in this randomized controlled trial patients were randomly allocated in the two arms of the study:one receiving interalesional glucantime injection weekly and the other receiving biweekly cryothrapy with intralesional injections of glucantime. at first, the lesion size and induration of lesions were recorded after 7 and 12 weeks, and treatment of lesions was monitored. healing was defined as complete re-epithelialisation and disappearance of induration. results: out of a total of 197 cl patientsm 112 cases with l. major were studied. 54 cases with 116 lesions received intralesional glucantime injection and 58 patients with 115 lesions received cryothrapy with intralesional injections of glucantime. at 7th week after the initiation of the treatment, complete healing was observed in56 out of 116 lesions (48.1%) in the group which received weekly intralesional ig injection and 83 out of 115 lesions (72.2%) in the group which received biweekly gi with ig&cryothrapy.; at 12th week after the initiation of the treatment, complete healing was observed in 105 out of 116 lesions (91%) in the group which received weekly intralesional ig injection and 115 out of 115 lesions (%100) in the group which received biweekly gi with ig & cryothrapy. by the end of 7th week, rr (0.95ci) amounted to 1.86(1.1 – 3.15) and at the end of 12th week they tapped to 3.4 (2.23- 2.27) which are statistically significant (p<0.02). the significant difference was observed between the two groups in terms of complete healing rate (p<0.05). conclusion: based on the findings, cryothrapy with biweekly intralesional injections of glucantime was more effective compared with weekly intercessional glucantime injection and reduced the period of treatment.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Evaluation of Intralesional Glucantime and Cryotherapy plus Intralesional Glucantime Therapeutic Efficacy on Zoonotic Cutaneous Leishmaniasis: A Randomized Clinical Trial

Background: Currently, Glucantime is considered the first-line treatment of cutaneous Leishmaniasis. This study aimed to evaluation of intralesional Glucantime (IG) and Cryotherapy (Cryo) plus intralesional Glucantime (Cryo and IG) therapeutic efficacy on Zoonotic Cutaneous Leishmaniasis in Qom province, Iran. Materials and Methods: In this randomized controlled trial of 197 CL patients reporte...

full text

The Efficacy of Co-administration of Topical Niosomal Dapsone Gel and Intralesional Injection of Glucantime in Cutaneous Leishmaniasis in Comparison with Cryotherapy Plus Intralesional Injection of Glucantime

Background & Aims: Leishmaniasis exists in more than half of Iran provinces and more than 20,000 cases are reported annually. In the recent years, several therapeutic approaches such as topical and physical treatments have been investigated. In the present study, the efficacy of co-administration of topical Niosomal Dapsone gel and Glucantime intralesional injection has been evaluated. Method: ...

full text

Topical Trichloroacetic Acid compared with intralesional Glucantime injection in the treatment of acute wet cutaneous Leishmaniasis: An open clinical trial

Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients with clinical diagnosis of wet cutaneous leishmaniasis in the age range of 5 to 75 years we...

full text

Efficacy of combined triple therapy (Paramomycin ointment, cryotherapy and intralesional Glucantime) in comparison with intralesional Glucantime for the treatment of acute cutaneous Leishmaniasis

Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment and intralesional Glucantime in the treatment of CL. Materials and methods: 157 patien...

full text

A comparison between cryotherapy alone and combined with intralesional Glucantime injection in the treatment of papulonodular Leishmaniasis

Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and Methods: 300 patients with CL were randomly assigned to two treatment groups in this clini...

full text

The efficacy of topical treatment with concentrated boiled extract and Hydroalcoholic extract of cassia fistula in comparison with intralesional injection of Glucantime in the treatment of acute Leishmaniasis

Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, the efficacy of concentrated boiled extract and hydro alcoholic extract of Cassi...

full text

My Resources

Save resource for easier access later


Journal title:
دانش و تندرستی

جلد ۸، شماره ۲، صفحات ۰-۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023